Searchable abstracts of presentations at key conferences in endocrinology

ea0090p652 | Endocrine-related Cancer | ECE2023

Characterization of splicing machinery components in thyroid cancer and their correlation/association with tumour behaviour and clinical features

Di Caro Isidoro , Sarmento-Cabral Andre , E. G-Garcia Miguel , Martinez Vara Andrea , Maria Moyano-Sanchez Ana , Sanchez-Sanchez Rafael , Romero Lluch Ana , Santisteban Sanz Pilar , Navarro Gonzalez Elena , Angeles Galvez Moreno Maria , M. Luque Raul , Jesus Martinez-Fuentes Antonio

Emerging evidence indicates that the cellular machinery controlling the splicing process (spliceosome) is altered in several tumour types, leading to oncogenic splicing events associated with tumour progression and aggressiveness. However, whether this molecular phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, our main aim was to explore the potential dysregulation of the expression of relevant spliceosome components and splicing factors in clinic...